Platelet function testing in acute cardiac care - is there a role for prediction or prevention of stent thrombosis and bleeding?

Thromb Haemost. 2015 Feb;113(2):221-30. doi: 10.1160/TH14-05-0449. Epub 2014 Nov 20.

Abstract

The role of platelet function testing in acute coronary syndrome patients undergoing percutaneous coronary intervention remains controversial despite the fact that high platelet reactivity is an independent predictor of stent thrombosis and emerging evidence suggests also a link between low platelet reactivity and bleeding. In this expert opinion paper, the Study Group on Biomarkers in Cardiology of the Acute Cardiovascular Care Association and the Working Group on Thrombosis of the European Society of Cardiology aim to provide an overview of current evidence in this area and recommendations for practicing clinicians.

Keywords: Antiplatelet agents; acute myocardial infarction; platelet pharmacology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Coronary Syndrome / complications*
  • Acute Coronary Syndrome / therapy
  • Cardiology / methods
  • Cardiology / standards*
  • Europe
  • Hemorrhage / diagnosis
  • Hemorrhage / prevention & control*
  • Humans
  • Odds Ratio
  • Percutaneous Coronary Intervention / adverse effects
  • Platelet Aggregation Inhibitors / therapeutic use
  • Platelet Function Tests / methods*
  • Practice Guidelines as Topic
  • Prognosis
  • Stents / adverse effects*
  • Thrombosis / diagnosis
  • Thrombosis / prevention & control*

Substances

  • Platelet Aggregation Inhibitors