A deeper look into translation initiation

Cell. 2014 Oct 23;159(3):475-6. doi: 10.1016/j.cell.2014.10.005.

Abstract

Eukaryotic translation initiation requires coordinated assembly of a remarkable array of initiation factors onto the small ribosomal subunit to select an appropriate mRNA start codon. Studies from Erzberger et al. and Hussain et al. bring new insights into this mechanism by looking at early and late initiation intermediates.

Publication types

  • Comment

MeSH terms

  • Animals
  • Eukaryotic Initiation Factor-1 / chemistry*
  • Eukaryotic Initiation Factor-3 / chemistry*
  • Eukaryotic Initiation Factors / metabolism*
  • Humans
  • Kluyveromyces / metabolism*
  • Peptide Chain Initiation, Translational*
  • Ribosome Subunits, Small, Eukaryotic / chemistry*
  • Saccharomyces cerevisiae / chemistry*
  • Saccharomyces cerevisiae / metabolism*
  • Saccharomyces cerevisiae Proteins / chemistry*

Substances

  • Eukaryotic Initiation Factor-1
  • Eukaryotic Initiation Factor-3
  • Eukaryotic Initiation Factors
  • Saccharomyces cerevisiae Proteins