Identification of rhabdoviral sequences in oropharyngeal swabs from German and Danish bats

Virol J. 2014 Nov 25:11:196. doi: 10.1186/s12985-014-0196-x.

Abstract

Background: In the frame of active lyssavirus surveillance in bats, oropharyngeal swabs from German (N = 2297) and Danish (N = 134) insectivorous bats were investigated using a newly developed generic pan-lyssavirus real-time reverse transcriptase PCR (RT-qPCR).

Findings: In total, 15 RT-qPCR positive swabs were detected. Remarkably, sequencing of positive samples did not confirm the presence of bat associated lyssaviruses but revealed nine distinct novel rhabdovirus-related sequences.

Conclusions: Several novel rhabdovirus-related sequences were detected both in German and Danish insectivorous bats. The results also prove that the novel generic pan-lyssavirus RT-qPCR offers a very broad detection range that allows the collection of further valuable data concerning the broad and complex diversity within the family Rhabdoviridae.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Chiroptera / virology*
  • Denmark
  • Germany
  • Molecular Sequence Data
  • Oropharynx / virology*
  • RNA, Viral / genetics
  • Real-Time Polymerase Chain Reaction
  • Reverse Transcriptase Polymerase Chain Reaction
  • Rhabdoviridae / isolation & purification*
  • Rhabdoviridae Infections / veterinary*
  • Rhabdoviridae Infections / virology
  • Sequence Analysis, DNA

Substances

  • RNA, Viral

Associated data

  • GENBANK/KJ614421
  • GENBANK/KJ614422
  • GENBANK/KJ614423
  • GENBANK/KJ614424
  • GENBANK/KJ614425
  • GENBANK/KJ614426
  • GENBANK/KJ614427
  • GENBANK/KJ873057
  • GENBANK/KJ873058