Cd(II)-terpyridine-based complex as a ratiometric fluorescent probe for pyrophosphate detection in solution and as an imaging agent in living cells

Dalton Trans. 2015 Jan 21;44(3):1358-65. doi: 10.1039/c4dt03022b.

Abstract

The terpyridine anthracene ligand was synthesized and characterized. is a ratiometric fluorescent probe for Cd(2+) with a recognition mechanism based on intramolecular charge transfer (ICT). An complex was isolated, and its structure was established using single-crystal XRD. The complex was able to serve as a novel reversible chemosensing ensemble to allow ratiometric response to pyrophosphate (PPi) in aqueous media. Moreover, the fluorescence imaging in living cells from these two emission channels suggested that was a ratiometric probe for Cd(2+), and the in situ generated complex was also a ratiometric ensemble for PPi detection in living cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cadmium / chemistry*
  • Cell Line
  • Coordination Complexes / chemical synthesis
  • Coordination Complexes / chemistry*
  • Coordination Complexes / metabolism
  • Crystallography, X-Ray
  • Diphosphates / analysis*
  • Fluorescent Dyes / chemistry*
  • Mice
  • Microscopy, Confocal*
  • Molecular Conformation
  • Pyridines / chemistry
  • Solutions / chemistry
  • Spectrometry, Fluorescence*

Substances

  • Coordination Complexes
  • Diphosphates
  • Fluorescent Dyes
  • Pyridines
  • Solutions
  • Cadmium
  • diphosphoric acid
  • pyridine