Constitutive phosphorylation of the active Notch1 intracellular domain in chronic lymphocytic leukemia cells with NOTCH1 mutation

Leukemia. 2015 Apr;29(4):994-8. doi: 10.1038/leu.2014.329. Epub 2014 Nov 26.

Authors

F De Falco¹, R Sabatini¹, F Falzetti², M Di Ianni³, P Sportoletti², S Baldoni², B Del Papa², I Screpanti⁴, P Marconi¹, E Rosati¹

Affiliations

¹ Department of Experimental Medicine, Biosciences and Medical Embryology Section, University of Perugia, Perugia, Italy.
² Department of Medicine, Hematology and Clinical Immunology Section, University of Perugia, Perugia, Italy.
³ Department of Life, Health and Environmental Sciences, Hematology Section, University of L'Aquila, L'Aquila, Italy.
⁴ Department of Molecular Medicine, University La Sapienza, Rome, Italy.

PMID: 25425197
DOI: 10.1038/leu.2014.329

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Casein Kinase II / antagonists & inhibitors
Casein Kinase II / genetics
Casein Kinase II / metabolism
Gene Expression Regulation, Leukemic*
Gene Frequency
Glycogen Synthase Kinase 3 / antagonists & inhibitors
Glycogen Synthase Kinase 3 / genetics
Glycogen Synthase Kinase 3 / metabolism
Glycogen Synthase Kinase 3 beta
Humans
Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
Leukemia, Lymphocytic, Chronic, B-Cell / metabolism
Leukemia, Lymphocytic, Chronic, B-Cell / pathology
Mutation*
Phosphatidylinositol 3-Kinases / genetics
Phosphatidylinositol 3-Kinases / metabolism
Phosphoinositide-3 Kinase Inhibitors
Phosphorylation
Protein Kinase Inhibitors / pharmacology
Protein Structure, Tertiary
Proto-Oncogene Proteins c-akt / antagonists & inhibitors
Proto-Oncogene Proteins c-akt / genetics
Proto-Oncogene Proteins c-akt / metabolism
Receptor, Notch1 / genetics*
Receptor, Notch1 / metabolism

Substances

NOTCH1 protein, human
Phosphoinositide-3 Kinase Inhibitors
Protein Kinase Inhibitors
Receptor, Notch1
Casein Kinase II
Glycogen Synthase Kinase 3 beta
Proto-Oncogene Proteins c-akt
Glycogen Synthase Kinase 3