Microfluidic continuous-flow radiosynthesis of [18F]FPEB suitable for human PET imaging

Steven H Liang; Daniel L Yokell; Raul N Jackson; Peter A Rice; Ronald Callahan; Keith A Johnson; David Alagille; Gilles Tamagnan; Thomas Lee Collier; Neil Vasdev

doi:10.1039/C3MD00335C

Microfluidic continuous-flow radiosynthesis of [¹⁸F]FPEB suitable for human PET imaging

Medchemcomm. 2014 Apr 1;5(4):432-435. doi: 10.1039/C3MD00335C.

Affiliations

¹ Department of Radiology, Harvard Medical School, 55 Fruit Street, Boston, MA, USA, 02114 ; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114.
² Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114.
³ Molecular NeuroImaging, LLC, New Haven, CT, 06510 ; Institute for Neurodegenerative Disorders, New Haven, CT, 06510.
⁴ Department of Radiology, Harvard Medical School, 55 Fruit Street, Boston, MA, USA, 02114 ; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114 ; Advion Inc., 10 Brown Road, Ithaca, NY, 14850.

Abstract

The synthesis of fluorine-18 labeled 3-fluoro-5-[(pyridin-3-yl)ethynyl] benzonitrile ([¹⁸F]FPEB) for imaging metabotropic glutamate receptor subtype type 5 (mGluR5) was achieved with a commercial continuous-flow microfluidics device. This work represents the first positron emission tomography (PET) radiopharmaceutical that is suitable for human use with this technology. We also describe a validated synthesis of [¹⁸F]FPEB with a commercial reactor-based system.

Microfluidic continuous-flow radiosynthesis of [¹⁸F]FPEB suitable for human PET imaging

Authors

Affiliations

Abstract

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