A novel reverse genetics system for human norovirus

Stefan Taube; Christiane E Wobus

doi:10.1016/j.tim.2014.10.001

A novel reverse genetics system for human norovirus

Trends Microbiol. 2014 Nov;22(11):604-6. doi: 10.1016/j.tim.2014.10.001. Epub 2014 Oct 16.

Authors

Stefan Taube¹, Christiane E Wobus²

Affiliations

¹ Institute for Virology and Cell Biology, University of Lübeck, 23562 Lübeck, Germany.
² Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: [email protected].

Abstract

Human noroviruses cause significant morbidity, mortality, and economic losses worldwide. The inability to grow human noroviruses in cell culture has hampered our collective understanding of virus-host interactions and development of therapeutics. A newly described single-plasmid reverse genetics system for noroviruses has the potential to facilitate basic and applied research.

Keywords: generation of reporter-tagged viruses; norovirus reverse genetics system.

MeSH terms

Animals
Cell Line
Genetic Vectors
Humans
Norovirus / genetics*
Norovirus / growth & development*
Plasmids
Reverse Genetics / methods*

Abstract

MeSH terms

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