Evidence for a functional role of alpha-1 adrenoceptors in the regulation of melatonin secretion in man

E Palazidou; C Franey; J Arendt; S Stahl; S Checkley

doi:10.1016/0306-4530(89)90062-0

Evidence for a functional role of alpha-1 adrenoceptors in the regulation of melatonin secretion in man

Psychoneuroendocrinology. 1989;14(1-2):131-5. doi: 10.1016/0306-4530(89)90062-0.

Authors

E Palazidou¹, C Franey, J Arendt, S Stahl, S Checkley

Affiliation

¹ Institute of Psychiatry, De Crespigny Park, London, U.K.

PMID: 2543998
DOI: 10.1016/0306-4530(89)90062-0

Abstract

Nocturnal plasma melatonin concentrations were reduced following administration of the alpha 1 adrenoceptor antagonist, prazosin (2 mg orally at 1900h), to 10 normal men. These data indicate that alpha 1 adrenoceptors are involved in the physiological control of melatonin secretion in man.

MeSH terms

Administration, Oral
Adult
Circadian Rhythm / drug effects
Humans
Male
Melatonin / blood*
Pineal Gland / drug effects
Pineal Gland / physiology*
Prazosin / pharmacology
Receptors, Adrenergic / drug effects
Receptors, Adrenergic / physiology*

Substances

Receptors, Adrenergic
Melatonin
Prazosin