Thrombotic manifestations in SAPHO syndrome. Review of the literature

Reumatol Clin. 2015 Mar-Apr;11(2):108-11. doi: 10.1016/j.reuma.2014.07.003. Epub 2014 Nov 22.
[Article in English, Spanish]

Abstract

SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome is a cluster of osteo-cutaneous manifestations that can lead to serious complications such as thrombosis of the subclavian vein or superior vena cava, mainly in patients with significant inflammatory involvement of the anterior-chest-wall. The objective of this study was to review the cases published in the medical literature related with the presence of thrombotic complications in patients diagnosed with SAPHO syndrome and to try to determine their possible pathogenic mechanism and risk factors. We analyzed 11 published reports of isolated clinical cases or case series, a total of 144 patients, which described a total of 15 cases of venous thrombosis. The clinical characteristics of these patients, evaluated to determine whether they meet the ASAS criteria for axial and peripheral spondyloarthritis, is analyzed the need for early diagnosis and treatment is highlighted.

Keywords: SAPHO syndrome; Subclavian vein; Superior vena cava; Síndrome SAPHO; Thrombosis; Trombosis; Vena cava superior; Vena subclavia.

Publication types

  • Review

MeSH terms

  • Acquired Hyperostosis Syndrome / complications*
  • Humans
  • Risk Factors
  • Subclavian Vein*
  • Vena Cava, Superior*
  • Venous Thrombosis / etiology*