Congenital multifocal rhabdoid tumor: a case with peculiar biological behavior and different response to treatment according to location (central nervous system and kidney)

Cancer Genet. 2014 Sep;207(9):441-4. doi: 10.1016/j.cancergen.2014.08.003. Epub 2014 Aug 24.

Abstract

Atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system and malignant rhabdoid tumor of the kidney (MRTK) may present with different responses to chemotherapy and outcomes. We describe the case of an infant with multifocal rhabdoid tumor with different behavior and response to treatment, depending on the anatomic site.

Keywords: AT/RT; MRTK; Rhabdoid tumor.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / therapeutic use*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Brain Neoplasms / congenital
  • Brain Neoplasms / genetics
  • Brain Neoplasms / pathology
  • Brain Neoplasms / therapy*
  • Cerebellum / diagnostic imaging
  • Cerebellum / pathology
  • Chromosomal Proteins, Non-Histone / genetics
  • Codon, Nonsense / genetics
  • Combined Modality Therapy
  • DNA-Binding Proteins / genetics
  • Humans
  • Infant
  • Kidney Neoplasms / congenital
  • Kidney Neoplasms / genetics
  • Kidney Neoplasms / pathology
  • Kidney Neoplasms / therapy*
  • Male
  • Radiography
  • Rhabdoid Tumor / congenital
  • Rhabdoid Tumor / genetics
  • Rhabdoid Tumor / pathology
  • Rhabdoid Tumor / therapy*
  • SMARCB1 Protein
  • Teratoma / congenital
  • Teratoma / genetics
  • Teratoma / pathology
  • Teratoma / therapy*
  • Transcription Factors / genetics

Substances

  • Antineoplastic Agents
  • Chromosomal Proteins, Non-Histone
  • Codon, Nonsense
  • DNA-Binding Proteins
  • SMARCB1 Protein
  • SMARCB1 protein, human
  • Transcription Factors

Supplementary concepts

  • Teratoid Tumor, Atypical