Repair mechanisms help glioblastoma resist treatment

Ryan J Atkins; Wayne Ng; Stanley S Stylli; Christopher M Hovens; Andrew H Kaye

doi:10.1016/j.jocn.2014.09.003

Repair mechanisms help glioblastoma resist treatment

J Clin Neurosci. 2015 Jan;22(1):14-20. doi: 10.1016/j.jocn.2014.09.003. Epub 2014 Nov 28.

Authors

Ryan J Atkins¹, Wayne Ng², Stanley S Stylli², Christopher M Hovens³, Andrew H Kaye²

Affiliations

¹ Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3050, Australia. Electronic address: [email protected].
² Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3050, Australia; Department of Neurosurgery, The Royal Melbourne Hospital, Parkville, VIC, Australia.
³ Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3050, Australia; Australian Prostate Cancer Research Centre at Epworth, Richmond, VIC, Australia.

PMID: 25444993
DOI: 10.1016/j.jocn.2014.09.003

Abstract

Glioblastoma multiforme (GBM) is a malignant and incurable glial brain tumour. The current best treatment for GBM includes maximal safe surgical resection followed by concomitant radiotherapy and adjuvant temozolomide. Despite this, median survival is still only 14-16 months. Mechanisms that lead to chemo- and radio-resistance underpin treatment failure. Insights into the DNA repair mechanisms that permit resistance to chemoradiotherapy in GBM may help improve patient responses to currently available therapies.

Keywords: Base excision repair; Glioma resistance; MGMT; PARP; Temozolomide chemotherapy.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Brain Neoplasms* / drug therapy
Brain Neoplasms* / metabolism
Brain Neoplasms* / radiotherapy
Brain Neoplasms* / surgery
DNA Modification Methylases / metabolism*
DNA Repair Enzymes / metabolism*
DNA Repair*
Glioblastoma* / drug therapy
Glioblastoma* / metabolism
Glioblastoma* / radiotherapy
Glioblastoma* / surgery
Humans
Poly(ADP-ribose) Polymerases / metabolism*
Tumor Suppressor Proteins / metabolism*

Substances

Tumor Suppressor Proteins
DNA Modification Methylases
MGMT protein, human
Poly(ADP-ribose) Polymerases
DNA Repair Enzymes