Susceptibility profiles of amphotericin B and posaconazole against clinically relevant mucorales species under hypoxic conditions

Elisabeth Maurer; Ulrike Binder; Manuela Sparber; Michaela Lackner; Rita Caramalho; Cornelia Lass-Flörl

doi:10.1128/AAC.04424-14

Susceptibility profiles of amphotericin B and posaconazole against clinically relevant mucorales species under hypoxic conditions

Antimicrob Agents Chemother. 2015 Feb;59(2):1344-6. doi: 10.1128/AAC.04424-14. Epub 2014 Dec 1.

Authors

Elisabeth Maurer¹, Ulrike Binder², Manuela Sparber¹, Michaela Lackner¹, Rita Caramalho¹, Cornelia Lass-Flörl¹

Affiliations

¹ Division of Hygiene and Medical Microbiology, Medical University Innsbruck, Innsbruck, Austria.
² Division of Hygiene and Medical Microbiology, Medical University Innsbruck, Innsbruck, Austria [email protected].

Abstract

The effect of hypoxic conditions on the in vitro efficacy of amphotericin B and posaconazole against Mucorales was evaluated by defining MICs with Etest and broth microdilution and identifying minimal fungicidal concentrations (MFCs). With Etest, oxygen-dependent changes were detected, while the MIC and the MFC determined with broth microdilution remained unaltered with reduced oxygen levels. The observed differences depended on the method used.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amphotericin B / pharmacology*
Antifungal Agents / pharmacology*
Cell Hypoxia / physiology
Microbial Sensitivity Tests
Mucorales / drug effects*
Triazoles / pharmacology*

Substances

Antifungal Agents
Triazoles
posaconazole
Amphotericin B