Abstract
Several lines of investigation identify common features of Creutzfeldt-Jakob disease, Alzheimer disease, and retroviral CNS infections. We discuss salient neuropathological, genetic, transmission, and transformation properties that suggest there may be common pathways in the pathogenesis of dementias. We also briefly present potential retroviral mechanisms that may be implicated in all of these dementias.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Acquired Immunodeficiency Syndrome / complications*
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Alzheimer Disease / genetics
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Alzheimer Disease / microbiology*
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Alzheimer Disease / pathology
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Animals
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Brain Diseases / etiology*
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Brain Diseases / pathology
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Creutzfeldt-Jakob Syndrome / genetics
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Creutzfeldt-Jakob Syndrome / microbiology*
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Creutzfeldt-Jakob Syndrome / pathology
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Humans
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Retroviridae Infections / pathology*