Hematopoietic stem cell transplantation rescues the immunologic phenotype and prevents vasculopathy in patients with adenosine deaminase 2 deficiency

J Allergy Clin Immunol. 2015 Jan;135(1):283-7.e5. doi: 10.1016/j.jaci.2014.10.010. Epub 2014 Nov 25.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Deaminase / blood
  • Adenosine Deaminase / deficiency*
  • Adenosine Deaminase / genetics
  • Adenosine Deaminase / immunology
  • Agammaglobulinemia / blood
  • Agammaglobulinemia / genetics
  • Agammaglobulinemia / immunology
  • Agammaglobulinemia / therapy*
  • Child, Preschool
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Infant
  • Intercellular Signaling Peptides and Proteins / blood
  • Intercellular Signaling Peptides and Proteins / deficiency*
  • Intercellular Signaling Peptides and Proteins / genetics
  • Interleukin-6 / blood
  • Lymphocyte Count
  • Male
  • Mutation
  • Phenotype
  • Severe Combined Immunodeficiency / blood
  • Severe Combined Immunodeficiency / genetics
  • Severe Combined Immunodeficiency / immunology
  • Severe Combined Immunodeficiency / therapy*

Substances

  • IL6 protein, human
  • Intercellular Signaling Peptides and Proteins
  • Interleukin-6
  • ADA2 protein, human
  • Adenosine Deaminase

Supplementary concepts

  • Severe combined immunodeficiency due to adenosine deaminase deficiency