Invasive lung cancer staging: influence of CT-guided core needle biopsy on onset of pleural carcinomatosis

Paul Flechsig; Josef Kunz; Claus-Peter Heussel; Farastuk Bozorgmehr; Philipp Schnabel; Hendrik Dienemann; Hans-Ulrich Kauczor; Oliver Sedlaczek

doi:10.1016/j.clinimag.2014.10.005

Invasive lung cancer staging: influence of CT-guided core needle biopsy on onset of pleural carcinomatosis

Clin Imaging. 2015 Jan-Feb;39(1):56-61. doi: 10.1016/j.clinimag.2014.10.005. Epub 2014 Oct 16.

Authors

Paul Flechsig¹, Josef Kunz², Claus-Peter Heussel², Farastuk Bozorgmehr³, Philipp Schnabel⁴, Hendrik Dienemann⁵, Hans-Ulrich Kauczor⁶, Oliver Sedlaczek⁶

Affiliations

¹ Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany; Member of the German Center for Lung Research DZL, Translational Lung Research Center Heidelberg, Heidelberg, Germany. Electronic address: [email protected].
² Member of the German Center for Lung Research DZL, Translational Lung Research Center Heidelberg, Heidelberg, Germany; Division of Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik at Heidelberg University, Heidelberg, Germany.
³ Member of the German Center for Lung Research DZL, Translational Lung Research Center Heidelberg, Heidelberg, Germany; Division of Oncology, Thoraxklinik at Heidelberg University, Heidelberg, Germany.
⁴ Member of the German Center for Lung Research DZL, Translational Lung Research Center Heidelberg, Heidelberg, Germany; Department of General Pathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
⁵ Member of the German Center for Lung Research DZL, Translational Lung Research Center Heidelberg, Heidelberg, Germany; Division of Thoracic Surgery, Thoraxklinik at Heidelberg University, Heidelberg, Germany.
⁶ Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany; Member of the German Center for Lung Research DZL, Translational Lung Research Center Heidelberg, Heidelberg, Germany.

PMID: 25457543
DOI: 10.1016/j.clinimag.2014.10.005

Abstract

In lung cancer patients with single peripheral lesions, CT-guided needle biopsies (CTNBs) are common for histological sampling. Recently published studies showed conflicting results for the influence of CTNB on the onset of pleural carcinomatosis (PC). In order to estimate the influence of CTNB on pleural tumor spread, 146 histologically confirmed cases of lung cancer diagnosed by CTNB were retrospectively compared to 112 control lung cancer patients diagnosed by non-CTNB. CTNB was not associated with an earlier onset of PC, identifying CTNB as a safe procedure for minimally invasive lung cancer staging.

Keywords: Biopsy; Computed tomography; Lung cancer; Pleural carcinomatosis; Tumor spread.

MeSH terms

Adult
Aged
Biopsy, Large-Core Needle / methods
Carcinoma / diagnostic imaging
Carcinoma / pathology*
Female
Humans
Image-Guided Biopsy / methods
Lung / diagnostic imaging
Lung / pathology*
Lung Neoplasms / diagnostic imaging
Lung Neoplasms / pathology*
Male
Middle Aged
Neoplasm Staging
Retrospective Studies
Tomography, X-Ray Computed