Clinical heterogeneity in the same generation of siblings with GCK/MODY 2

Giulio Maltoni; Stefano Zucchini; Anna Lisa Martini; Elena Marasco; Vilma Mantovani; Andrea Pession

doi:10.1016/j.diabres.2014.11.002

Clinical heterogeneity in the same generation of siblings with GCK/MODY 2

Diabetes Res Clin Pract. 2015 Jan;107(1):e1-3. doi: 10.1016/j.diabres.2014.11.002. Epub 2014 Nov 13.

Authors

Giulio Maltoni¹, Stefano Zucchini², Anna Lisa Martini², Elena Marasco³, Vilma Mantovani³, Andrea Pession²

Affiliations

¹ Departement of Pediatrics, St. Orsola-Malpighi University Hospital, via Massarenti 11, 40138 Bologna, Italy. Electronic address: [email protected].
² Departement of Pediatrics, St. Orsola-Malpighi University Hospital, via Massarenti 11, 40138 Bologna, Italy.
³ Center for Applied Biomedical Research (CRBA), St. Orsola-Malpighi University Hospital, via Massarenti 9, 40138 Bologna, Italy.

PMID: 25467089
DOI: 10.1016/j.diabres.2014.11.002

Abstract

We report a peculiar case of a GCK/MODY2 family in whom monogenic and autoimmune diabetes coexist and exert different effects on clinical pictures, passing from mild hyperglycaemia not requiring any treatment through occasional insulin administration to complete insulin dependent type 1 diabetes.

Keywords: Autoimmunity; Diabetes; Glucokinase.

Publication types

Case Reports

MeSH terms

Child, Preschool
Diabetes Mellitus, Type 1 / drug therapy
Diabetes Mellitus, Type 1 / enzymology*
Diabetes Mellitus, Type 1 / genetics
Diabetes Mellitus, Type 2 / drug therapy
Diabetes Mellitus, Type 2 / enzymology*
Diabetes Mellitus, Type 2 / genetics
Female
Glucokinase / genetics*
Glucokinase / metabolism
Humans
Hyperglycemia / enzymology
Hyperglycemia / genetics
Insulin / therapeutic use

Substances

Insulin
Glucokinase

Supplementary concepts

Maturity-Onset Diabetes of the Young, Type 2