Combined therapy with peritoneal dialysis and hemodialysis: a multicenter retrospective observational cohort study in Japan

Blood Purif. 2014;38(2):149-53. doi: 10.1159/000368389. Epub 2014 Nov 29.

Abstract

Background/aims: Combining peritoneal dialysis (PD) and hemodialysis (HD) has been common treatment option in Japan.

Methods: In this retrospective, multicenter, observational study, the clinical characteristics and outcomes of 104 patients (57 ± 11 years, males 72%) who had switched from PD alone to combined therapy with PD and HD were studied. Clinical parameters were measured at baseline and after 3 months of combined therapy.

Results: At baseline, urine volume, dialysate-to-plasma ratio of creatinine (D/P Cr), and total Kt/V were 150 ml/day (range: 0-2,000 ml/day), 0.67 ± 0.11, and 1.8 ± 0.4, respectively. During the first 3 months of combined therapy, body weight, urine volume, serum creatinine level, and D/P Cr decreased, whereas hemoglobin levels increased.

Conclusions: In patients where PD does not result in acceptable outcomes, combined therapy with PD and HD may have potential benefits in terms of dialysis adequacy and hydration status. Video Journal Club “Cappuccino with Claudio Ronco” at http://www.karger.com/?doi=368389

Publication types

  • Multicenter Study
  • Observational Study

MeSH terms

  • Aged
  • Creatinine / blood*
  • Female
  • Hemodialysis Solutions / chemistry
  • Humans
  • Kidney Failure, Chronic / blood
  • Kidney Failure, Chronic / pathology
  • Kidney Failure, Chronic / physiopathology
  • Kidney Failure, Chronic / therapy*
  • Male
  • Middle Aged
  • Peritoneal Dialysis*
  • Renal Dialysis
  • Retrospective Studies
  • Urinalysis

Substances

  • Hemodialysis Solutions
  • Creatinine