IL-18 is not therapeutic for neovascular age-related macular degeneration

Yoshio Hirano; Tetsuhiro Yasuma; Takeshi Mizutani; Benjamin J Fowler; Valeria Tarallo; Reo Yasuma; Younghee Kim; Ana Bastos-Carvalho; Nagaraj Kerur; Bradley D Gelfand; Sasha Bogdanovich; Shikun He; Xiaohui Zhang; Miho Nozaki; Ryo Ijima; Hiroki Kaneko; Yuichiro Ogura; Hiroko Terasaki; Hiroshi Nagai; Isao Haro; Gabriel Núñez; Balamurali K Ambati; David R Hinton; Jayakrishna Ambati

doi:10.1038/nm.3671

IL-18 is not therapeutic for neovascular age-related macular degeneration

Nat Med. 2014 Dec;20(12):1372-5. doi: 10.1038/nm.3671.

Authors

Yoshio Hirano¹, Tetsuhiro Yasuma¹, Takeshi Mizutani², Benjamin J Fowler¹, Valeria Tarallo³, Reo Yasuma¹, Younghee Kim¹, Ana Bastos-Carvalho¹, Nagaraj Kerur¹, Bradley D Gelfand⁴, Sasha Bogdanovich¹, Shikun He⁵, Xiaohui Zhang⁶, Miho Nozaki², Ryo Ijima⁷, Hiroki Kaneko⁷, Yuichiro Ogura², Hiroko Terasaki⁷, Hiroshi Nagai⁸, Isao Haro⁹, Gabriel Núñez¹⁰, Balamurali K Ambati¹¹, David R Hinton⁵, Jayakrishna Ambati¹²

Affiliations

¹ Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, Kentucky, USA.
² Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
³ 1] Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, Kentucky, USA. [2] Institute of Genetics and Biophysics Adriano Buzzati-Traverso, Consiglio Nazionale delle Ricerche (CNR), Naples, Italy.
⁴ 1] Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, Kentucky, USA. [2] Department of Biomedical Engineering, University of Kentucky, Lexington, Kentucky, USA. [3] Department of Microbiology, Immunology and Human Genetics, University of Kentucky, Lexington, Kentucky, USA.
⁵ 1] Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA. [2] Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
⁶ Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, USA.
⁷ Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
⁸ Division of Dermatology, Kobe University School of Medicine, Chuo-ku, Kobe, Japan.
⁹ Department of Urology, Wakayama Medical University, Wakayama, Japan.
¹⁰ Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, USA.
¹¹ 1] Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, USA. [2] Department of Ophthalmology, Veterans Affairs Salt Lake City Healthcare System, Salt Lake City, Utah, USA.
¹² 1] Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, Kentucky, USA. [2] Department of Physiology, University of Kentucky, Lexington, Kentucky, USA.

PMID: 25473914
PMCID: PMC4275546
DOI: 10.1038/nm.3671

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Comment

MeSH terms

Animals
Choroidal Neovascularization / drug therapy*
Choroidal Neovascularization / prevention & control*
Humans
Interleukin-18 / therapeutic use*
Macular Degeneration / drug therapy*

Substances

Interleukin-18

Publication types

MeSH terms

Substances

Grants and funding