An epigenetic therapy for diffuse intrinsic pontine gliomas

Vijay Ramaswamy; Marc Remke; Michael D Taylor

doi:10.1038/nm.3769

An epigenetic therapy for diffuse intrinsic pontine gliomas

Nat Med. 2014 Dec;20(12):1378-9. doi: 10.1038/nm.3769.

Authors

Vijay Ramaswamy¹, Marc Remke¹, Michael D Taylor¹

Affiliation

¹ Division of Neurosurgery, Hospital for Sick Children, Toronto, Ontario, Canada.

PMID: 25473916
DOI: 10.1038/nm.3769

Abstract

Diffuse intrinsic pontine glioma is a uniformly lethal malignant tumor of infancy with no effective therapies. A new study reveals that inhibition of JMJD3 has robust antitumor activity in diffuse intrinsic pontine glioma xenografts.

Publication types

Comment

MeSH terms

Animals
Apoptosis / drug effects*
Benzazepines / pharmacology*
Brain Stem Neoplasms / genetics*
Cell Proliferation / drug effects*
Gene Expression Regulation, Neoplastic*
Glioma / genetics*
Histones / drug effects*
Humans
Jumonji Domain-Containing Histone Demethylases / antagonists & inhibitors*
Pyrimidines / pharmacology*

Substances

Benzazepines
GSK-J4
Histones
Pyrimidines
Jumonji Domain-Containing Histone Demethylases
KDM6B protein, human