[3H]MK-801 binding sites in postmortem brain regions of schizophrenic patients

J Neural Transm. 1989;77(2-3):231-6. doi: 10.1007/BF01248936.

Abstract

[3H]MK-801 binding was used as a marker for the NMDA receptorion channel complex in postmortem brain samples from the frontal cortex, hippocampus, putamen, entorhinal region, and amygdala of schizophrenic patients and controls. In schizophrenia [3H]MK-801 binding levels were increased in all brain regions investigated reaching significance in the putamen.

MeSH terms

  • Aged
  • Anticonvulsants / metabolism*
  • Brain Chemistry*
  • Dibenzocycloheptenes / metabolism*
  • Dizocilpine Maleate
  • Female
  • Humans
  • Male
  • Receptors, N-Methyl-D-Aspartate
  • Receptors, Neurotransmitter / metabolism*
  • Schizophrenia / metabolism*

Substances

  • Anticonvulsants
  • Dibenzocycloheptenes
  • Receptors, N-Methyl-D-Aspartate
  • Receptors, Neurotransmitter
  • Dizocilpine Maleate