Genetic diversity among simian immunodeficiency virus isolates from African green monkeys

P R Johnson; M Gravell; J Allan; S Goldstein; R A Olmsted; G Dapolito; C McGann; W T London; R H Purcell; V M Hirsch

Genetic diversity among simian immunodeficiency virus isolates from African green monkeys

J Med Primatol. 1989;18(3-4):271-7.

Authors

P R Johnson¹, M Gravell, J Allan, S Goldstein, R A Olmsted, G Dapolito, C McGann, W T London, R H Purcell, V M Hirsch

Affiliation

¹ Department of Microbiology, Georgetown University, Washington, DC.

PMID: 2547962

Abstract

To characterize isolates further within the SIVagm subtype, we studied four SIVagm isolates by cross-hybridization, molecular cloning, and nucleotide sequencing. Our results indicate an unexpected degree of genetic variation among isolates within the SIVagm subtype comparable to the variation between SIVmac and HIV-2.

MeSH terms

Animals
Base Sequence
Blotting, Southern
Cercopithecus / microbiology*
Chlorocebus aethiops / microbiology*
Cloning, Molecular
Cross Reactions
DNA, Viral / genetics
Genetic Variation*
Monkey Diseases / microbiology*
Nucleic Acid Hybridization
Restriction Mapping
Retroviridae Infections / microbiology
Retroviridae Infections / veterinary*
Simian Immunodeficiency Virus / genetics*
Simian Immunodeficiency Virus / isolation & purification

Substances

DNA, Viral