Abstract
Findings are reviewed, relevant to elucidation of the pathogenic, genetic and biochemical properties of a single, genetically heterogeneous isolate of feline leukemia virus (FeLV-FAIDS) shown to induce fatal immunodeficiency disease in nearly 100% of inoculated cats. Hypotheses are suggested which pertain to the mechanism of T-cell killing by this virus, and which extrapolate findings in the FeLV-FAIDS animal model to AIDS induced in humans by human immunodeficiency virus (HIV).
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Acquired Immunodeficiency Syndrome
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Animals
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Cat Diseases / immunology*
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Cat Diseases / microbiology
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Cats
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Disease Models, Animal
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Genes, Viral
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Immunologic Deficiency Syndromes / immunology
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Immunologic Deficiency Syndromes / microbiology
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Immunologic Deficiency Syndromes / veterinary*
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Leukemia / immunology
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Leukemia / microbiology
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Leukemia / veterinary*
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Leukemia Virus, Feline / genetics
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Leukemia Virus, Feline / immunology
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Leukemia Virus, Feline / isolation & purification
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Leukemia Virus, Feline / pathogenicity*
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Retroviridae Infections / immunology
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Retroviridae Infections / microbiology
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Retroviridae Infections / veterinary*