Using the MEROPS Database for Proteolytic Enzymes and Their Inhibitors and Substrates

Curr Protoc Bioinformatics. 2014 Dec 12:48:1.25.1-1.25.33. doi: 10.1002/0471250953.bi0125s48.

Abstract

MEROPS is a database of proteolytic enzymes as well as their inhibitors and substrates. Proteolytic enzymes and protein inhibitors are organized into protein domain families. In turn, families are organized into clans. Each peptidase, inhibitor, family, and clan has associated annotation, a multiple sequence alignment, a phylogenetic tree, literature references, and links to other databases. Interactions between proteolytic enzymes and inhibitors and between proteolytic enzymes and substrates are also presented. The entries in MEROPS are available via the World Wide Web. This unit contains detailed information on how to access and utilize the information present in the MEROPS database. Details on running MEROPS both remotely and locally are presented.

Keywords: inhibitor; peptidase; protease; proteolytic enzyme; substrate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Databases, Protein*
  • Molecular Sequence Data
  • Peptide Hydrolases / chemistry*
  • Peptide Hydrolases / metabolism
  • Protease Inhibitors / chemistry*
  • Sequence Homology, Amino Acid
  • Substrate Specificity
  • User-Computer Interface

Substances

  • Protease Inhibitors
  • Peptide Hydrolases