[Hereditary angioedema in childhood. Diagnosis and therapeutic challenges]

Anne Pagnier

doi:10.1016/j.lpm.2014.07.018

[Hereditary angioedema in childhood. Diagnosis and therapeutic challenges]

Presse Med. 2015 Jan;44(1):89-95. doi: 10.1016/j.lpm.2014.07.018. Epub 2014 Dec 12.

[Article in French]

Author

Anne Pagnier¹

Affiliation

¹ CHU de Grenoble, hôpital couple enfants, clinique universitaire de pédiatrie, Centre national de référence des angioedèmes (CREAK), boulevard de la Chantourne, 38043 Grenoble cedex 09, France. Electronic address: [email protected].

PMID: 25511651
DOI: 10.1016/j.lpm.2014.07.018

Abstract

Hereditary angioedema is a rare disease. In case of laryngeal edema or chronic abdominal pains, diagnosis is difficult in childhood because numerous differential diagnoses possibilities are to be considered. The diagnosis of hereditary angioedema with normal C1Inh (type III) is also a challenge because it is based only on clinical features. Important school absenteeism can be due to recurrent abdominal attacks. Early diagnosis, specific management, and therapeutic education are necessary for improvement of quality of life. Actually, subcutaneous treatment is not yet available for children. Studies are going on. In the meantime, C1Inh concentrate intravenous administration must be available for children quickly and safely.

Publication types

English Abstract
Review

MeSH terms

Adolescent
Age Factors
Age of Onset
Angioedemas, Hereditary / diagnosis*
Angioedemas, Hereditary / epidemiology
Angioedemas, Hereditary / therapy*
Child
Child, Preschool
Clinical Laboratory Techniques / methods
Early Diagnosis
Humans