Fabrication of nano-structured calcium silicate coatings with enhanced stability, bioactivity and osteogenic and angiogenic activity

Xiuhui Wang; Yuning Zhou; Lunguo Xia; Cancan Zhao; Lei Chen; Deliang Yi; Jiang Chang; Liping Huang; Xuebin Zheng; Huiying Zhu; Youtao Xie; Yuanjin Xu; Kaili Lin

doi:10.1016/j.colsurfb.2014.11.044

Fabrication of nano-structured calcium silicate coatings with enhanced stability, bioactivity and osteogenic and angiogenic activity

Colloids Surf B Biointerfaces. 2015 Feb 1:126:358-66. doi: 10.1016/j.colsurfb.2014.11.044. Epub 2014 Dec 4.

Authors

Xiuhui Wang¹, Yuning Zhou², Lunguo Xia², Cancan Zhao¹, Lei Chen¹, Deliang Yi¹, Jiang Chang¹, Liping Huang³, Xuebin Zheng³, Huiying Zhu¹, Youtao Xie⁴, Yuanjin Xu⁵, Kaili Lin⁶

Affiliations

¹ State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.
² Department of Oral and Maxillofacial Surgery, College of Stomatology, 9(th) People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China.
³ Laboratory of Inorganic Coating Materials, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.
⁴ Laboratory of Inorganic Coating Materials, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China. Electronic address: [email protected].
⁵ Department of Oral and Maxillofacial Surgery, College of Stomatology, 9(th) People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China. Electronic address: [email protected].
⁶ State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China. Electronic address: [email protected].

PMID: 25516266
DOI: 10.1016/j.colsurfb.2014.11.044

Abstract

The bioactivity and stability of coatings on alloy implants play critical roles in the fast osseointegration and maintenance of a long-term life span of the implants, respectively. Herein, nano-sheet surface on bioactive calcium silicate (CaSiO3, CS) coatings on metal substrates was fabricated by combining atmosphere plasma spraying (APS) and hydrothermal technology (HT). The glassy phase in CS coatings generated by APS was converted into crystalline sheet-like nano-structures after HT treatment. Compared with the original CS coating samples, HT treatment decreased the degradation rate of the CS coatings. Moreover, the fabricated nano-structured topography of CS coatings increased the apatite mineralization ability and significantly enhanced the cell attachment, proliferation, differentiation, alkaline phosphatase (ALP) activity and expression of osteogenic genes and angiogenic factors of rat bone marrow stromal cells (bMSCs). Our results suggest that the nano-structured CS coatings have immense potential in improving the clinical performance of medical implants.

Keywords: Angiogenic activity; Calcium silicate coating; Nano-structured surface; Osteogenic activity; Stability.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Angiogenesis Inducing Agents / chemistry*
Angiogenesis Inducing Agents / pharmacology*
Animals
Calcium Compounds / chemistry*
Calcium Compounds / pharmacology*
Cells, Cultured
Mesenchymal Stem Cells / cytology
Mesenchymal Stem Cells / drug effects*
Mesenchymal Stem Cells / metabolism
Molecular Structure
Nanostructures / chemistry*
Osteogenesis / drug effects*
Rats
Silicates / chemistry*
Silicates / pharmacology*
Surface Properties
Temperature

Substances

Angiogenesis Inducing Agents
Calcium Compounds
Silicates
calcium silicate