Tumors STING adaptive antitumor immunity

Immunity. 2014 Nov 20;41(5):679-81. doi: 10.1016/j.immuni.2014.11.004. Epub 2014 Nov 20.

Abstract

Immunotherapy is revolutionizing the treatment of cancer patients, but the molecular basis for tumor immunogenicity is unclear. In this issue of Immunity, Deng et al. (2014) and Woo et al. (2014) provide evidence suggesting that dendritic cells detect DNA from tumor cells via the STING-mediated, cytosolic DNA sensing pathway.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • CD8-Positive T-Lymphocytes / immunology*
  • DNA / immunology*
  • Lymphocyte Activation / immunology*
  • Melanoma, Experimental / immunology*
  • Membrane Proteins / genetics*
  • Membrane Proteins / immunology*
  • Neoplasms / radiotherapy*
  • Nucleotidyltransferases / immunology*

Substances

  • Membrane Proteins
  • Sting1 protein, mouse
  • DNA
  • Nucleotidyltransferases
  • cGAS protein, mouse