Looks can be deceiving: reconsidering the evidence for gliotransmission

Steven A Sloan; Ben A Barres

doi:10.1016/j.neuron.2014.12.003

Looks can be deceiving: reconsidering the evidence for gliotransmission

Neuron. 2014 Dec 17;84(6):1112-5. doi: 10.1016/j.neuron.2014.12.003.

Authors

Steven A Sloan¹, Ben A Barres²

Affiliations

¹ Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305-5125, USA. Electronic address: [email protected].
² Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305-5125, USA.

Abstract

Gliotransmission, a process involving active vesicular release of glutamate and other neurotransmitters by astrocytes, is thought to play a critical role in many brain functions. A new paper by Nedergaard et al. (2014) identifies an experimental flaw in these previous studies suggesting that astrocytes may not perform active vesicular release after all.

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Comment

MeSH terms

Animals
Female
Gene Expression Regulation*
Male
Neurons / metabolism*
SNARE Proteins / biosynthesis*

Substances

SNARE Proteins

Abstract

Publication types

MeSH terms

Substances

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