Abstract
Murine studies suggest a role for the NLRP3 inflammasome in obesity-driven airway inflammation; human studies are lacking. Our findings demonstrate that human in vivo ozone-induced airway and systemic inflammation, measured by IL-1β, correlates with BMI.
Publication types
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Letter
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Asthma / immunology*
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Body Mass Index*
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Cell Count
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Eosinophils / cytology
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Forced Expiratory Volume / drug effects
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Humans
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Interleukin-1beta / blood*
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Interleukin-6 / blood
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Interleukin-8 / blood
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Neutrophils / cytology
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Obesity
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Ozone / pharmacology
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Ozone / toxicity*
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Retrospective Studies
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Spirometry
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Sputum / chemistry*
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Vital Capacity / drug effects
Substances
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CXCL8 protein, human
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IL1B protein, human
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IL6 protein, human
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Interleukin-1beta
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Interleukin-6
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Interleukin-8
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Ozone