Resemble and Inhibit: when RLR meets TGF-β

Shu Zhu; Hua-Bing Li; Richard A Flavell

doi:10.1016/j.molcel.2014.12.010

Resemble and Inhibit: when RLR meets TGF-β

Mol Cell. 2014 Dec 18;56(6):719-20. doi: 10.1016/j.molcel.2014.12.010.

Authors

Shu Zhu¹, Hua-Bing Li¹, Richard A Flavell²

Affiliations

¹ Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
² Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA. Electronic address: [email protected].

PMID: 25526529
DOI: 10.1016/j.molcel.2014.12.010

Abstract

In this issue, Xu et al. (2014) show that innate antiviral RIG-I-like receptors (RLR) signaling represses TGF-β-induced growth inhibition, epithelial-mesenchyme transition (EMT), and regulatory T cell (Treg) differentiation via IRF3-mediated Smads function.

Publication types

Comment

MeSH terms

Animals
Humans
Interferon Regulatory Factor-3 / physiology*
Sendai virus / immunology*
Smad3 Protein / metabolism*
Transforming Growth Factor beta / physiology*

Substances

IRF3 protein, human
Interferon Regulatory Factor-3
SMAD3 protein, human
Smad3 Protein
Transforming Growth Factor beta