Breast carcinoma with positive results for melanoma marker (HMB-45). HMB-45 immunoreactivity in normal and neoplastic breast

F Bonetti; R Colombari; E Manfrin; G Zamboni; G Martignoni; A Mombello; M Chilosi

doi:10.1093/ajcp/92.4.491

Breast carcinoma with positive results for melanoma marker (HMB-45). HMB-45 immunoreactivity in normal and neoplastic breast

Am J Clin Pathol. 1989 Oct;92(4):491-5. doi: 10.1093/ajcp/92.4.491.

Authors

F Bonetti¹, R Colombari, E Manfrin, G Zamboni, G Martignoni, A Mombello, M Chilosi

Affiliation

¹ Istituto di Anatomia Patologica, Universitá di Verona, Italy.

PMID: 2552794
DOI: 10.1093/ajcp/92.4.491

Abstract

HMB-45 (melanocytic cell-specific monoclonal antibody) immunoreactivity has been detected by the immunoperoxidase technique in the cytoplasm of 2 of 100 breast carcinomas. In addition, normal breast lobules and ducts were occasionally found to have positive results in 6 of 100 cases. These findings indicate the need to exercise caution in the interpretation of HMB-45 immunoreactivity for immunohistochemical characterization of neoplasms.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Monoclonal*
Biomarkers, Tumor / analysis*
Breast / analysis*
Carcinoma / analysis*
Carcinoma / pathology
Carcinoma, Intraductal, Noninfiltrating / analysis*
Carcinoma, Intraductal, Noninfiltrating / pathology
Female
Fibrocystic Breast Disease / analysis*
Fibrocystic Breast Disease / pathology
Humans
Immunoenzyme Techniques
Melanocytes / analysis*
Retrospective Studies

Substances

Antibodies, Monoclonal
Biomarkers, Tumor