Stereospecific ligands and their complexes. XXII. Synthesis and antitumor activity of palladium(II) complexes with some esters of (S,S)-ethylenediamine-N,N'-di-(2,2'-di(4-hydroxy-benzyl))-acetic acid

J Inorg Biochem. 2015 Feb:143:111-6. doi: 10.1016/j.jinorgbio.2014.12.001. Epub 2014 Dec 10.

Abstract

Four new ligands and their palladium(II) complexes of general formula R2-S,S-eddtyr (L1-L4) and [PdCl2(R2-S,S-eddtyr)] (C1-C4) (R=ethyl, n-propyl, n-butyl and n-pentyl; S,S-eddtyr·2HCl=ethylenediamine-N,N'-di-(2,2'-di(4-hydroxy-benzyl))-acetic acid dihydrochloride have been synthesized and characterized by microanalysis, infrared, (1)H and (13)C NMR spectroscopy. Cytotoxicity for ligands and complexes on two different cell lines (human breast cancer, MDA-MB-231 and human lung cancer, A549 cell lines) and human chronic lymphocytic leukemia cells (CLL) was investigated using MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay.

Keywords: (1)H and (13)C NMR spectroscopy; Cytotoxicity; Infrared spectroscopy; Palladium(II) complexes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetates* / chemical synthesis
  • Acetates* / chemistry
  • Acetates* / pharmacology
  • Antineoplastic Agents* / chemical synthesis
  • Antineoplastic Agents* / chemistry
  • Antineoplastic Agents* / pharmacology
  • Cell Line, Tumor
  • Cytotoxins* / chemical synthesis
  • Cytotoxins* / chemistry
  • Cytotoxins* / pharmacology
  • Drug Screening Assays, Antitumor
  • Female
  • Humans
  • Male
  • Neoplasms / drug therapy*
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Palladium / chemistry
  • Palladium / pharmacology
  • Stereoisomerism

Substances

  • Acetates
  • Antineoplastic Agents
  • Cytotoxins
  • Palladium