Abstract
The antiplatelet activity of some 1,8-naphthyridine derivatives was studied. The compounds displayed different abilities in blocking the effects of ADP, collagen and arachidonic acid. Four of them showed an in vitro remarkable activity similar to that of dipyridamole and papaverine.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3',5'-Cyclic-AMP Phosphodiesterases / metabolism
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Animals
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Cattle
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Chemical Phenomena
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Chemistry
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Dipyridamole / pharmacology
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Heart / drug effects
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In Vitro Techniques
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Male
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Myocardium / enzymology
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Naphthyridines / chemical synthesis
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Naphthyridines / pharmacology*
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Papaverine / pharmacology
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Platelet Aggregation Inhibitors* / chemical synthesis
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Rabbits
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Rats
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Rats, Inbred Strains
Substances
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Naphthyridines
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Platelet Aggregation Inhibitors
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Dipyridamole
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Papaverine
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3',5'-Cyclic-AMP Phosphodiesterases