Distribution of [3H]MK801 binding in the normal aged human hippocampus

M Johnson; R H Perry; F G Charlton; M A Moses; J A Court; E K Perry

doi:10.1016/0006-8993(89)91151-7

Distribution of [3H]MK801 binding in the normal aged human hippocampus

Brain Res. 1989 Oct 9;499(1):184-7. doi: 10.1016/0006-8993(89)91151-7.

Authors

M Johnson¹, R H Perry, F G Charlton, M A Moses, J A Court, E K Perry

Affiliation

¹ MRC Neurochemical Pathology Unit, Newcastle General Hospital, U.K.

PMID: 2553207
DOI: 10.1016/0006-8993(89)91151-7

Abstract

The distribution of NMDA receptors in the normal human hippocampus has been investigated using the non-competitive channel blocking agent, MK801. The pattern of specific [3H]MK801 binding was broadly similar to that previously described for agonist binding although differences included equal densities in h1 and h2 regions where binding was mainly confined to the pyramidal layer and stratum radiatum.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Aging / metabolism*
Dibenzocycloheptenes / metabolism*
Dizocilpine Maleate
Hippocampus / growth & development
Hippocampus / metabolism*
Humans
Receptors, N-Methyl-D-Aspartate
Receptors, Neurotransmitter / metabolism*
Receptors, Neurotransmitter / physiology

Substances

Dibenzocycloheptenes
Receptors, N-Methyl-D-Aspartate
Receptors, Neurotransmitter
Dizocilpine Maleate