Motor neuron disease in 2014. Biomarkers for ALS--in search of the Promised Land

Nat Rev Neurol. 2015 Feb;11(2):72-4. doi: 10.1038/nrneurol.2014.250. Epub 2014 Dec 23.

Abstract

The past year has seen some extraordinary activity in clinical amyotrophic lateral sclerosis (ALS) research. Two trials were completed, with negative results, but the discovery of novel ALS-associated genes, and body fluid and imaging biomarkers warrants cautious optimism. Here, we provide a snapshot of some of the main findings in 2014.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amyotrophic Lateral Sclerosis / diagnosis*
  • Amyotrophic Lateral Sclerosis / drug therapy*
  • Amyotrophic Lateral Sclerosis / genetics
  • Amyotrophic Lateral Sclerosis / metabolism*
  • Biomarkers / metabolism*
  • Clinical Trials as Topic
  • Humans
  • Research

Substances

  • Biomarkers