A new causative bacteria of infective endocarditis, Bergeyella cardium sp. nov

Kyung Mok Sohn; Kyungmin Huh; Jin-Yang Baek; Yeon-Sook Kim; Cheol-In Kang; Kyong Ran Peck; Nam Yong Lee; Jae-Hoon Song; Kwan Soo Ko; Doo Ryeon Chung

doi:10.1016/j.diagmicrobio.2014.12.001

A new causative bacteria of infective endocarditis, Bergeyella cardium sp. nov

Diagn Microbiol Infect Dis. 2015 Mar;81(3):213-6. doi: 10.1016/j.diagmicrobio.2014.12.001. Epub 2014 Dec 12.

Authors

Affiliations

¹ Division of Infectious Diseases, Chungnam National University Hospital, Daejeon, Republic of Korea.
² Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
³ Asia Pacific Foundation for Infectious Diseases (APFID), Seoul, Republic of Korea.
⁴ Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
⁵ Asia Pacific Foundation for Infectious Diseases (APFID), Seoul, Republic of Korea; Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea. Electronic address: [email protected].
⁶ Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address: [email protected].

PMID: 25544000
DOI: 10.1016/j.diagmicrobio.2014.12.001

Abstract

The first cases of infective endocarditis due to a new species of Bergeyella, Bergeyella cardium sp. nov., are reported. Two strains, 13-07(T) (= JCM 30115(T) = NCCP 15908(T)) and 13-16, were independently isolated from 2 patients in different hospitals in Korea. Initially, the isolates were identified as Brevundimonas spp.; however, their 16S rRNA gene sequences shared a similarity of 94.9% with Bergeyella zoohelcum, implying that they are a new species belonging to of the genus Bergeyella. The organisms might be susceptible to many commonly used antibiotics, including penicillin. The first case was successfully treated with ceftriaxone, and the second, with piperacillin/tazobactam plus amikacin.

Keywords: Bergeyella; Ceftriaxone; Infective endocarditis; Piperacillin/tazobactam.

Publication types

Case Reports

MeSH terms

Adult
Anti-Bacterial Agents / pharmacology
Anti-Bacterial Agents / therapeutic use
Ceftriaxone / therapeutic use
Cluster Analysis
DNA, Bacterial / chemistry
DNA, Bacterial / genetics
DNA, Ribosomal / chemistry
DNA, Ribosomal / genetics
Endocarditis / diagnosis*
Endocarditis / microbiology*
Flavobacteriaceae / classification*
Flavobacteriaceae / genetics
Flavobacteriaceae / isolation & purification*
Hospitals
Humans
Korea
Male
Microbial Sensitivity Tests
Middle Aged
Molecular Sequence Data
Penicillanic Acid / analogs & derivatives
Penicillanic Acid / therapeutic use
Phylogeny
Piperacillin / therapeutic use
Piperacillin, Tazobactam Drug Combination
RNA, Ribosomal, 16S / genetics
Sequence Analysis, DNA
Treatment Outcome

Substances

Anti-Bacterial Agents
DNA, Bacterial
DNA, Ribosomal
RNA, Ribosomal, 16S
Piperacillin, Tazobactam Drug Combination
Ceftriaxone
Penicillanic Acid
Piperacillin

Associated data

GENBANK/KJ817166
GENBANK/KJ817167