Identification of the source of A (H10N8) virus causing human infection

Yifei Xu; Huabin Cao; Hongyan Liu; Hailiang Sun; Brigitte Martin; Yulong Zhao; Qi Wang; Guangfu Deng; Jianli Xue; Yibo Zong; Jing Zhu; Feng Wen; Li-Ping Long; Sook-San Wong; Nan Zhao; Xiaoshan Fu; Ming Liao; Guoliang Hu; Richard Webby; George F Gao; Xiu-Feng Wan

doi:10.1016/j.meegid.2014.12.026

Identification of the source of A (H10N8) virus causing human infection

Infect Genet Evol. 2015 Mar:30:159-163. doi: 10.1016/j.meegid.2014.12.026. Epub 2014 Dec 27.

Authors

Yifei Xu¹, Huabin Cao², Hongyan Liu², Hailiang Sun³, Brigitte Martin³, Yulong Zhao³, Qi Wang², Guangfu Deng², Jianli Xue³, Yibo Zong², Jing Zhu², Feng Wen³, Li-Ping Long³, Sook-San Wong⁴, Nan Zhao³, Xiaoshan Fu⁵, Ming Liao⁶, Guoliang Hu⁷, Richard Webby⁴, George F Gao⁸, Xiu-Feng Wan⁹

Affiliations

¹ College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi 330045, China; Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762, USA.
² College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi 330045, China.
³ Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762, USA.
⁴ Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
⁵ Jiangxi Provincial Center for Animal Disease Control and Prevention, Nanchang, Jiangxi 300006, China.
⁶ College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong 510642, China.
⁷ College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi 330045, China. Electronic address: [email protected].
⁸ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, China Academy of Sciences, Beijing 100190, China; Office of Director-General, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China.
⁹ College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi 330045, China; Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762, USA; Institute for Genomics, Biocomputing and Biotechnology, Mississippi State University, Mississippi State, MS 39762, USA. Electronic address: [email protected].

Abstract

A novel H10N8 influenza A virus has been detected in three humans in China since December 2013. Although this virus was hypothesized to be a novel reassortant among influenza viruses from wild birds and domestic poultry, its evolutionary path leading to human infection is unknown. Sporadic surveillance at the live poultry market (LPM) suspected to be the source of infection for the first H10N8 patient has shown a gradual increase in influenza virus prevalence culminating with a predominance of H10N8 viruses. Influenza viruses detected in the LPM up to 8 months prior to human infection contributed genetic components to the zoonotic virus. These H10N8 viruses have continued to evolve within this LPM subsequent to the human infection, and continuous assessments of these H10N8 viruses will be necessary. Serological surveillance showed that the virus appears to have been present throughout the LPM system in Nanchang, China. Reduction of the influenza virus burden in LPMs is essential in preventing future emergence of novel influenza viruses with zoonotic and pandemic potential.

Keywords: Avian influenza virus; H10N8; Human infection; Live poultry market.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Animals
China
Humans
Influenza A Virus, H10N8 Subtype / classification*
Influenza A Virus, H10N8 Subtype / genetics*
Influenza A Virus, H10N8 Subtype / isolation & purification
Influenza in Birds / virology*
Influenza, Human / virology*
Phylogeny
Poultry / virology*

Abstract

Publication types

MeSH terms

Grants and funding