RNA sequencing reveals a unique fusion of the lysine (K)-specific methyltransferase 2A and smooth muscle myosin heavy chain 11 in myelodysplastic syndrome and acute myeloid leukemia

Haematologica. 2015 Jan;100(1):e1-3. doi: 10.3324/haematol.2014.110775.

Authors

Mathijs A Sanders¹, François G Kavelaars¹, Annelieke Zeilemaker¹, Adil S A Al Hinai¹, Saman Abbas¹, H Berna Beverloo¹, Kirsten van Lom¹, Peter J M Valk²

Affiliations

¹ Department of Hematology and Clinical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands.
² Department of Hematology and Clinical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands [email protected].

No abstract available

Keywords: KMT2A; MYH11; acute myeloid leukemia; mutations; myelodysplastic syndrome.

Publication types

Case Reports
Letter

MeSH terms

Aged
Follow-Up Studies
Gene Fusion
High-Throughput Nucleotide Sequencing / methods*
Histone-Lysine N-Methyltransferase / genetics*
Humans
Leukemia, Myeloid, Acute / genetics*
Leukemia, Myeloid, Acute / pathology
Leukemia, Myeloid, Acute / therapy
Myelodysplastic Syndromes / genetics*
Myelodysplastic Syndromes / pathology
Myelodysplastic Syndromes / therapy
Myeloid-Lymphoid Leukemia Protein / genetics*
Myosin Heavy Chains / genetics*
Oncogene Proteins, Fusion / genetics*
Prognosis
Sequence Analysis, RNA / methods

Substances

KMT2A protein, human
MYH11 protein, human
Oncogene Proteins, Fusion
Myeloid-Lymphoid Leukemia Protein
Histone-Lysine N-Methyltransferase
Myosin Heavy Chains