Chronic lymphocytic leukemia cells in lymph nodes show frequent NOTCH1 activation

Haematologica. 2015 May;100(5):e200-3. doi: 10.3324/haematol.2014.117705. Epub 2014 Dec 31.
No abstract available

Keywords: NOTCH1 activation; chronic lymphocytic leukemia.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
  • Leukemia, Lymphocytic, Chronic, B-Cell / metabolism
  • Leukemia, Lymphocytic, Chronic, B-Cell / mortality
  • Leukemia, Lymphocytic, Chronic, B-Cell / pathology*
  • Lymph Nodes / metabolism*
  • Lymph Nodes / pathology*
  • Mutation
  • Mutation Rate
  • Phosphoproteins / genetics
  • Prognosis
  • RNA Splicing Factors
  • Receptor, Notch1 / genetics*
  • Receptor, Notch1 / metabolism
  • Ribonucleoprotein, U2 Small Nuclear / genetics
  • Transcriptional Activation*

Substances

  • Phosphoproteins
  • RNA Splicing Factors
  • Receptor, Notch1
  • Ribonucleoprotein, U2 Small Nuclear
  • SF3B1 protein, human