Unicentric, multifocal Castleman disease of the mediastinum associated with cerebellitis

Masatsugu Hamaji; Joel W Neal; Bryan M Burt

doi:10.1016/j.athoracsur.2014.10.028

Unicentric, multifocal Castleman disease of the mediastinum associated with cerebellitis

Ann Thorac Surg. 2015 Jan;99(1):e7-9. doi: 10.1016/j.athoracsur.2014.10.028.

Authors

Masatsugu Hamaji¹, Joel W Neal², Bryan M Burt³

Affiliations

¹ Department of Thoracic Surgery, Kyoto University, Kyoto, Japan.
² Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California.
³ Division of Thoracic Surgery, Department of Surgery, Baylor College of Medicine, Houston, Texas. Electronic address: [email protected].

PMID: 25555986
DOI: 10.1016/j.athoracsur.2014.10.028

Abstract

A 30-year-old man presented with rapidly progressive cerebellar symptoms. Brain magnetic resonance imaging was consistent with cerebellitis. A subsequent chest computed tomography revealed a multilobulated anterior mediastinal mass, which was diagnosed on the surgical biopsy specimen as hyaline vascular Castleman disease. After resection of the mediastinal mass and multiple involved adjacent mediastinal lymph nodes, the cerebellitis resolved. To the best of our knowledge, this is the first report of Castleman disease associated with cerebellitis. This rare case of suspected paraneoplastic cerebellitis related to a multifocal unicentric Castleman disease confined to the mediastinum is discussed.

Publication types

Case Reports

MeSH terms

Adult
Castleman Disease / complications*
Castleman Disease / pathology
Castleman Disease / surgery
Cerebellum*
Encephalitis / etiology*
Humans
Male
Mediastinal Diseases / complications*
Mediastinal Diseases / pathology
Mediastinal Diseases / surgery