δ,ε-Unsaturated α,β-diamino acids as building blocks for the asymmetric synthesis of diverse α,β-diamino acids

Nemai Saha; Bhaskar Chatterjee; Shital K Chattopadhyay

doi:10.1021/jo5022162

δ,ε-Unsaturated α,β-diamino acids as building blocks for the asymmetric synthesis of diverse α,β-diamino acids

J Org Chem. 2015 Feb 6;80(3):1896-904. doi: 10.1021/jo5022162. Epub 2015 Jan 15.

Authors

Nemai Saha¹, Bhaskar Chatterjee, Shital K Chattopadhyay

Affiliation

¹ Department of Chemistry, University of Kalyani , Kalyani-741235, West Bengal, India.

PMID: 25562112
DOI: 10.1021/jo5022162

Abstract

A building block approach for the synthesis of α,β-diamino acids is described, which involves the diastereodivergent preparation of two sets of orthogonally protected δ,ε-unsaturated α,β-diamino acids as templates for the preparation of 12 new α,β-diamino acids of biological relevance using simple techniques.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acids, Diamino / chemical synthesis*
Amino Acids, Diamino / chemistry*
Biochemical Phenomena
Molecular Structure
Stereoisomerism

Substances

Amino Acids, Diamino