DNA damage responses: beyond double-strand break repair

Andrea L Bredemeyer; Barry P Sleckman

doi:10.1016/j.cub.2014.11.024

DNA damage responses: beyond double-strand break repair

Curr Biol. 2015 Jan 5;25(1):R45-6. doi: 10.1016/j.cub.2014.11.024.

Authors

Andrea L Bredemeyer¹, Barry P Sleckman²

Affiliations

¹ Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Ave., Campus Box 8118, St. Louis, MO 63110-1093, USA.
² Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Ave., Campus Box 8118, St. Louis, MO 63110-1093, USA. Electronic address: [email protected].

PMID: 25562302
DOI: 10.1016/j.cub.2014.11.024

Abstract

The RAG endonuclease generates DNA double strand breaks during antigen receptor gene assembly, an essential process for B- and T-lymphocyte development. However, a recent study reveals that RAG endonuclease activity affects natural killer cell function, demonstrating that such double strand breaks, and the responses they elicit, may have broad cellular effects.

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MeSH terms

Animals
DNA-Binding Proteins / metabolism*
Homeodomain Proteins / metabolism*
Killer Cells, Natural / immunology*

Substances

DNA-Binding Proteins
Homeodomain Proteins