Abstract
“…in light of the result that ABCB5 helps to amplify a PAX6-positive limbal stem cell population … it will now be important to test whether ABCB5 selection could also enhance the conversion of skin epithelial stem cells to corneal epithelial stem cells.”
Keywords:
ABCB5; KRT12; PAX6; adult stem cell; cornea; corneal epithelial stem cells; knockout mouse; limbal stem cell deficiency; limbal stem cells; limbus; skin; stem cell therapy; transplantation.
Publication types
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Editorial
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism
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Biomarkers / metabolism
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Cell Separation
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Corneal Diseases / therapy
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Humans
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Limbus Corneae / cytology*
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Stem Cell Transplantation
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Stem Cells / cytology*
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Translational Research, Biomedical
Substances
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ABCB5 protein, human
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ATP Binding Cassette Transporter, Subfamily B
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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Biomarkers