Dysfunctional families: Clostridium scindens and secondary bile acids inhibit the growth of Clostridium difficile

K Leigh Greathouse; Curtis C Harris; Scott J Bultman

doi:10.1016/j.cmet.2014.12.016

Dysfunctional families: Clostridium scindens and secondary bile acids inhibit the growth of Clostridium difficile

Cell Metab. 2015 Jan 6;21(1):9-10. doi: 10.1016/j.cmet.2014.12.016.

Authors

K Leigh Greathouse¹, Curtis C Harris¹, Scott J Bultman²

Affiliations

¹ Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
² Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA. Electronic address: [email protected].

Abstract

C. difficile infection is a deadly disease that is influenced by the microbiome. In a recent article in Nature, Buffie et al. (2014) demonstrate that the ability of C. scindens to synthesize secondary bile acids is crucial to providing resistance to C. difficile infection.

Publication types

Comment

MeSH terms

Animals
Bile Acids and Salts / metabolism*
Clostridioides difficile / physiology*
Disease Susceptibility / microbiology*
Female
Humans
Intestinal Mucosa / metabolism*
Intestines / microbiology*
Microbiota / physiology*

Substances

Bile Acids and Salts

Grants and funding

Z01 BC005480-22/Intramural NIH HHS/United States