Abstract
Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, N.I.H., Intramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Butyrophilins
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Computational Biology
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Genome-Wide Association Study
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Genotype
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Humans
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Lymphoma, B-Cell, Marginal Zone / genetics*
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Major Histocompatibility Complex / genetics*
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Membrane Glycoproteins / genetics*
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Polymorphism, Single Nucleotide / genetics*
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White People / genetics*
Substances
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BTNL2 protein, human
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Butyrophilins
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Membrane Glycoproteins