Mx GTPases: dynamin-like antiviral machines of innate immunity

Trends Microbiol. 2015 Mar;23(3):154-63. doi: 10.1016/j.tim.2014.12.003. Epub 2015 Jan 6.

Abstract

The Mx dynamin-like GTPases are key antiviral effector proteins of the type I and type III interferon (IFN) systems. They inhibit several different viruses by blocking early steps of the viral replication cycle. We focus on new structural and functional insights and discuss recent data revealing that human MxA (MX1) provides a safeguard against introduction of avian influenza A viruses (FLUAV) into the human population. The related human MxB (MX2) serves as restriction factor for HIV-1 and other primate lentiviruses.

Keywords: HIV-1; dynamin-like GTPase; influenza; innate immunity; interferon; primate evolution.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Humans
  • Immunity, Innate*
  • Influenza A virus / immunology*
  • Models, Molecular
  • Myxovirus Resistance Proteins / chemistry*
  • Myxovirus Resistance Proteins / pharmacology
  • Myxovirus Resistance Proteins / physiology*
  • Orthomyxoviridae / growth & development
  • Orthomyxoviridae / immunology
  • Orthomyxoviridae / physiology*
  • Phylogeny
  • Virus Physiological Phenomena*
  • Virus Replication
  • Viruses / immunology

Substances

  • Myxovirus Resistance Proteins