Standardized perfusion value of the esophageal carcinoma and its correlation with quantitative CT perfusion parameter values

A Djuric-Stefanovic; Dj Saranovic; D Sobic-Saranovic; D Masulovic; V Artiko

doi:10.1016/j.ejrad.2014.12.004

Standardized perfusion value of the esophageal carcinoma and its correlation with quantitative CT perfusion parameter values

Eur J Radiol. 2015 Mar;84(3):350-359. doi: 10.1016/j.ejrad.2014.12.004. Epub 2014 Dec 15.

Authors

A Djuric-Stefanovic¹, Dj Saranovic², D Sobic-Saranovic³, D Masulovic⁴, V Artiko⁵

Affiliations

¹ Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Unit of Digestive Radiology (First University Surgical Clinic), Center of Radiology and MR, Clinical Center of Serbia, Belgrade, Serbia. Electronic address: [email protected].
² Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Unit of Digestive Radiology (First University Surgical Clinic), Center of Radiology and MR, Clinical Center of Serbia, Belgrade, Serbia. Electronic address: [email protected].
³ Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Center of Nuclear Medicine, Clinical Center of Serbia, Belgrade, Serbia. Electronic address: [email protected].
⁴ Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Unit of Digestive Radiology (First University Surgical Clinic), Center of Radiology and MR, Clinical Center of Serbia, Belgrade, Serbia. Electronic address: [email protected].
⁵ Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Center of Nuclear Medicine, Clinical Center of Serbia, Belgrade, Serbia. Electronic address: [email protected].

PMID: 25579474
DOI: 10.1016/j.ejrad.2014.12.004

Abstract

Purpose: Standardized perfusion value (SPV) is a universal indicator of tissue perfusion, normalized to the whole-body perfusion, which was proposed to simplify, unify and allow the interchangeability among the perfusion measurements and comparison between the tumor perfusion and metabolism. The aims of our study were to assess the standardized perfusion value (SPV) of the esophageal carcinoma, and its correlation with quantitative CT perfusion measurements: blood flow (BF), blood volume (BV), mean transit time (MTT) and permeability surface area product (PS) of the same tumor volume samples, which were obtained by deconvolution-based CT perfusion analysis.

Methods: Forty CT perfusion studies of the esophageal cancer were analyzed, using the commercial deconvolution-based CT perfusion software (Perfusion 3.0, GE Healthcare). The SPV of the esophageal tumor and neighboring skeletal muscle were correlated with the corresponding mean tumor and muscle quantitative CT perfusion parameter values, using Spearman's rank correlation coefficient (rS).

Results: Median SPV of the esophageal carcinoma (7.1; range: 2.8-13.4) significantly differed from the SPV of the skeletal muscle (median: 1.0; range: 0.4-2.4), (Z=-5.511, p<0.001). The cut-off value of the SPV of 2.5 enabled discrimination of esophageal cancer from the skeletal muscle with sensitivity and specificity of 100%. SPV of the esophageal carcinoma significantly correlated with corresponding tumor BF (rS=0.484, p=0.002), BV (rS=0.637, p<0.001) and PS (rS=0.432, p=0.005), and SPV of the skeletal muscle significantly correlated with corresponding muscle BF (rS=0.573, p<0.001), BV (rS=0.849, p<0.001) and PS (rS=0.761, p<0.001).

Conclusions: We presented a database of the SPV for the esophageal cancer and proved that SPV of the esophageal neoplasm significantly differs from the SPV of the skeletal muscle, which represented a sample of healthy tissue. The SPV was validated against quantitative CT perfusion measurements and statistically significant correlation was proved.

Keywords: CT perfusion; Deconvolution; Esophageal carcinoma; Standardized perfusion value.

Publication types

Comparative Study

MeSH terms

Blood Volume
Esophageal Neoplasms / complications
Esophageal Neoplasms / diagnostic imaging*
Esophageal Neoplasms / pathology
Humans
Male
Multidetector Computed Tomography*
Perfusion
Perfusion Imaging* / methods
Prospective Studies
Radiographic Image Enhancement / methods
Reproducibility of Results
Sensitivity and Specificity
Tomography, X-Ray Computed*