The relationship between dihydroorotic acid dehydrogenase and in vitro and in vivo cytostatic effects of brequinar sodium (DUP-785; NSC 368390)

Adv Exp Med Biol. 1989:253B:375-82. doi: 10.1007/978-1-4684-5676-9_55.
No abstract available

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology*
  • Biphenyl Compounds / pharmacology*
  • Colonic Neoplasms / enzymology
  • Dihydroorotate Oxidase / antagonists & inhibitors
  • Dihydroorotate Oxidase / metabolism*
  • Dose-Response Relationship, Drug
  • Humans
  • Mice
  • Oxidoreductases / metabolism*
  • Pyrimidine Nucleotides / analysis*
  • Tumor Cells, Cultured / drug effects
  • Tumor Cells, Cultured / enzymology*

Substances

  • Antineoplastic Agents
  • Biphenyl Compounds
  • Pyrimidine Nucleotides
  • brequinar
  • Oxidoreductases
  • Dihydroorotate Oxidase