Modular and highly stereoselective approach to all-carbon tetrasubstituted alkenes

Org Lett. 2015 Feb 6;17(3):608-11. doi: 10.1021/ol503624v. Epub 2015 Jan 14.

Abstract

A modular and completely stereoselective approach for the construction of all-carbon tetrasubstituted alkenes is described. It is based on the three-fold, sequential metal-catalyzed, cross-coupling functionalization of simple enolphosphate dibromide templates with carbon nucleophiles, affording tetrasubstituted alkenes as single isomers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemical synthesis*
  • Alkenes / chemistry*
  • Catalysis
  • Hydrocarbons, Brominated / chemistry*
  • Molecular Structure
  • Palladium / chemistry
  • Stereoisomerism

Substances

  • Alkenes
  • Hydrocarbons, Brominated
  • Palladium
  • palladium chloride