This study evaluates the influence of interimplant distance (ID) on patient satisfaction and quality of life (QOL) of 55 patients who received mandibular overdentures supported by two implants. IDs were measured over the residual ridge crest and linearly on all of the patients' mandibular casts. The crestal detours of all patients were determined by subtracting these two values from each other. Higher IDs were associated with better QOL scores (P < .05), whereas higher crestal detour values were associated with better general comfort, chewing, ease of hygiene maintenance, esthetics, pain, and QOL scores (P < .05).