Detection of a transient R292K mutation in influenza A/H3N2 viruses shed for several weeks by an immunocompromised patient

N Esther Babady; Jennifer M Laplante; Yi-Wei Tang; Kirsten St George

doi:10.1128/JCM.02845-14

Detection of a transient R292K mutation in influenza A/H3N2 viruses shed for several weeks by an immunocompromised patient

J Clin Microbiol. 2015 Apr;53(4):1415-8. doi: 10.1128/JCM.02845-14. Epub 2015 Jan 14.

Authors

N Esther Babady¹, Jennifer M Laplante², Yi-Wei Tang³, Kirsten St George²

Affiliations

¹ Clinical Microbiology Service, Department of Laboratory Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA [email protected].
² Laboratory of Viral Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
³ Clinical Microbiology Service, Department of Laboratory Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

Abstract

We describe the case of an immunocompromised patient, positive for influenza A virus (H3N2), in whom the neuraminidase R292K mutation was transiently detected during oseltamivir treatment. The R292K mutation was identified by direct testing in 3 of 11 respiratory specimens collected throughout the patient's illness but in none of the cultures from those specimens.

Publication types

Case Reports

MeSH terms

Antiviral Agents / therapeutic use
Gene Expression Regulation, Viral
Humans
Immunocompromised Host*
Influenza A Virus, H3N2 Subtype / genetics*
Influenza, Human / virology*
Male
Middle Aged
Mutation
Neuraminidase / genetics*
Oseltamivir / therapeutic use
Real-Time Polymerase Chain Reaction / methods
Reverse Transcriptase Polymerase Chain Reaction / methods
Virus Shedding

Substances

Antiviral Agents
Oseltamivir
Neuraminidase